Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 28  |  Issue : 1  |  Page : 9--14

Protective role of Nigella sativa in diabetic nephropathy: A randomized clinical trial


Zafar Masood Ansari1, Mohammad Nasiruddin1, Rahat Ali Khan1, Shahzad Faizul Haque2 
1 Department of Pharmacology, J. N. Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
2 Department of Medicine, J. N. Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

Correspondence Address:
Zafar Masood Ansari
Department of Pharmacology, J. N. Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh
India

This study aims to evaluate efficacy and safety of Nigella sativa oil supplementation in patients with chronic kidney disease Stage 3 and 4 due to diabetic nephropathy. It was a prospective, comparative, and open-label study. Patients were randomized into two groups. Group 1 (Control) received conservative management of diabetic nephropathy, whereas Group 2 (Test) received N. sativa oil (2.5 mL, once daily and per orally) along with conservative management for 12 weeks. Blood glucose, hemogram, and kidney function test were done at 0, 6, and 12 weeks of treatment. Significance of differences between pre- and post-treatment values in each group was assessed using Student«SQ»s paired t-test and between the groups using unpaired t-test. We found a drop in blood glucose, serum creatinine, blood urea, and 24 h total urinary protein levels and a rise in glomerular filtration rate, 24 h total urinary volume, and hemoglobin level in the treatment group compared to the control group.


How to cite this article:
Ansari ZM, Nasiruddin M, Khan RA, Haque SF. Protective role of Nigella sativa in diabetic nephropathy: A randomized clinical trial.Saudi J Kidney Dis Transpl 2017;28:9-14


How to cite this URL:
Ansari ZM, Nasiruddin M, Khan RA, Haque SF. Protective role of Nigella sativa in diabetic nephropathy: A randomized clinical trial. Saudi J Kidney Dis Transpl [serial online] 2017 [cited 2017 Mar 30 ];28:9-14
Available from: http://www.sjkdt.org/article.asp?issn=1319-2442;year=2017;volume=28;issue=1;spage=9;epage=14;aulast=Ansari;type=0