Home About us Current issue Ahead of Print Back issues Submission Instructions Advertise Contact Login   

Search Article 
Advanced search 
Saudi Journal of Kidney Diseases and Transplantation
Users online: 757 Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size 

REVIEW ARTICLE Table of Contents   
Year : 2001  |  Volume : 12  |  Issue : 1  |  Page : 32-41
Monitoring Immune Responses in Organ Recipients by Flow Cytometry

Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

Correspondence Address:
Khaled Al-Hussein
Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, MBC-03, P.O. Box 3354, Riyadh 11211
Saudi Arabia
Login to access the Email id

PMID: 18209358

Rights and Permissions

Allograft rejection remains a major barrier to successful organ transplan­tation. Cellular and humoral immune responses play a critical role in mediating graft rejection. During the last few years, monoclonal antibodies have been used as a new specific therapeutic approach in the prevention of allograft rejection. Recently, the technology of flow cytometry has become a useful tool for monitoring immunological responses in transplant recipients. The application of this valuable tool in clinical transplantation at the present time is aimed at, i) determining the extent of immuno­suppressive therapy through T-cell receptor analysis of cellular components, ii) monitoring levels of alloreactive antibodies to identify high-risk recipients (sensitized patients) in the pre-operative period and iii) to predict rejection by monitoring their development post­operatively. In future, further development of this technology may demonstrate greater benefit to the field of organ transplantation.

Print this article  Email this article

  Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   Citation Manager
  Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded545    
    Comments [Add]    

Recommend this journal