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Saudi Journal of Kidney Diseases and Transplantation
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ORIGINAL ARTICLE Table of Contents   
Year : 2003  |  Volume : 14  |  Issue : 1  |  Page : 18-22
Role of Sequential Biopsy Study in the Evaluation of Renal Transplant

1 Department of Pathology, Salmaniya Medical Centre, Manama, Bahrain
2 Department of Nephrology, Salmaniya Medical Centre, Manama, Bahrain

Correspondence Address:
Kamaraju Suguna Ratnakar
Department of Pathology, Salmaniya Medical Centre, P.O. Box 12, Manama
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Source of Support: None, Conflict of Interest: None

PMID: 17657085

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Renal biopsy is indicated in all cases of renal transplants showing renal dysfunction. This not only helps in the diagnosis but also in the institution of proper management. Study of sequential biopsies is essential for establishing the cause of renal dysfunction, evaluation of the effect of treatment and the progress of the disease. This report is based on the study of 14 samples (including three nephrectomy specimens) belonging to six patients who underwent two or more sequential renal transplant biopsies at the Salmaniya Medical Centre, Bahrain, between 1995-2000 because of deteriorating renal functions. Based on the sequential biopsies, the graft dysfunction was attributed to rejection in four cases and recurrence of primary glomerular disease in two. An important finding in this series is one case of type I membranoproliferative glomerulonephritis due to hepatitis C noticed five years after transplant and two cases of acute vascular rejection superimposed upon chronic rejection.

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