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| CASE REPORT |
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| Year : 2004 |
Volume
: 15 | Issue : 1 | Page
: 50-52 |
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Neuropsychiatric Manifestations in a Patient Undergoing Hemodialysis Caused by Treatment with Oral Acyclovir
Habib Skhiri, Abdellatif Achour, Sami Skhiri, Ameur Frih, Samia Bouraoui, Nasr Ben Dhia, Mezri Elmay
Department of Nephrology, Monastir Hospital, Monastir 5000, Tunisia
Correspondence Address:
Habib Skhiri
Department of Nephrology, Monastir Hospital, Monastir 5000
Tunisia
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 18202466 
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A 50-year-old woman who was being treated with hemodialysis was admitted for severe neuropsychiatric symptoms. She tested positive for antibody to hepatitis C virus. Her medical history revealed ophthalmic herpes zoster four days before her admission for which she was started on oral acyclovir (800 mg three times daily). Four days later, she became disoriented and agitated. She had visual hallucinations and myoclonus. She was diagnosed as having acyclovir toxicity and was instituted on vigorous dialysis. The serum acyclovir levels normalized and the patient became asymptomatic with three dialysis sessions. Our case further reinforces that the dose of acyclovir should be reduced in patients with renal failure and that dialysis is a good form of treatment for over dosage. |
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