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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2004  |  Volume : 15  |  Issue : 4  |  Page : 486-488
Varicella-Induced Remission of Steroid-Resistant Nephrotic Syndrome in a Child

Pediatric Nephrology Department, Kidney Hospital, Ibn Alnafis Medical Complex, Damascus, Syria

Correspondence Address:
Mohamad Bassam A Saeed
Kidney Hospital, P.O.Box 8292, Damascus
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Source of Support: None, Conflict of Interest: None

PMID: 17642785

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We report a Syrian boy aged three years and four months, a known case of the nephrotic syndrome (NS) diagnosed 18 months earlier. In view of non-response to steroid therapy administered according to the ISKDC regimen, a kidney biopsy was performed which showed features compatible with minimal change disease. While on alternate-day steroid therapy, he developed a typical rash of very severe varicella. Steroid therapy was stopped and intravenous acyclovir was administered for five days, followed by oral acyclovir. The child made a full recovery from chickenpox which was associated, in addition, with a complete remission of the NS. His remission has been sustained after a follow-up of six months. In conclusion, to the best of our knowledge and following an extended search, this case is the probably first ever published about varicella-induced remission of steroid-non responsive NS.

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