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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2004  |  Volume : 15  |  Issue : 4  |  Page : 489-493
Successful Bone Marrow Transplantation in a Child with X-Linked Hyper-IgM Syndrome

Department of Pediatrics, King Hussein medical Center, Amman, Jordan

Correspondence Address:
Haddadin Isam
Consultant Pediatric Oncologist, P.O.Box 926119, Amman 11190
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Source of Support: None, Conflict of Interest: None

PMID: 17642786

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A 13-year-old boy was diagnosed at the age of three years as having hyper IgM Immunodeficiency syndrome (HIgM). It is a rare congenital disease characterized by recurrent infections and very low level of serum immunoglobulin (IgG, IgA) and elevated IgM. Conservative treatment with antibiotics and regular intravenous immunoglobulin (IVIG) was not satisfactory. At the age of five, the patient developed Hodgkin's lymphoma, which was treated successfully with chemotherapy. Experience with Bone Marrow Transplantation (BMT) in such cases is limited as a definitive treatment for this kind of syndromes. He was transplanted from his HLA-matched sister, and three years post BMT follow-up he showed good clinical recovery and immunoreconstitution.

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