Up-Date on Renal Fibrosis: A Time for Action

E Nigel Wardle

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LETTER TO EDITOR

Year : 2007 | Volume : 18 | Issue : 2 | Page : 262

Up-Date on Renal Fibrosis: A Time for Action

E Nigel Wardle
London NW1 8JS, United Kingdom

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How to cite this article:
Wardle E N. Up-Date on Renal Fibrosis: A Time for Action. Saudi J Kidney Dis Transpl 2007;18:262

How to cite this URL:
Wardle E N. Up-Date on Renal Fibrosis: A Time for Action. Saudi J Kidney Dis Transpl [serial online] 2007 [cited 2023 Jan 29];18:262. Available from: https://www.sjkdt.org/text.asp?2007/18/2/262/32322

To the Editor:

Readers of my original article [1] may have concluded that on the subject of Fibrosis there is a vast amount of theoretical information, [2] but for the working nephrologists there is only the knowledge that treating patients with a combination of ACE inhibitors and ARBs could lessen fibrosis, or alternatively there is the Et-1 antagonist bosentan, which is not entirely free of side-effects.

However there is encouraging news. It is reported that mycophenolate inhibits mesangial cell proliferation and reduces the synthesis of extracellular matrix. [3] Then low dose rapamycin has been found to act similarly, albeit by a different mechanism. [4] Finally when type II diabetics are taking glibenclamide this agent stops extracellular matrix formation by mesangial cells exposed to a high glucose. [5]

References

1.	Wardle E N. Renal Fibrosis, Origin and possible Interventions:A Time for Action. Saudi J Kidney Dis Transpl 2006;17{2}:137-48.
2.	Teng Y, Zeisberg M, Kalluri R. Transcriptional regulation of epithelialmesenchymal transition. J Clin Invest 2007;117:304-6. [PUBMED] [FULLTEXT]
3.	Ha H, Kim M S, Park J, et al. Mycophenolic acid inhibits mesangial cell activation through p38 MAPkinase inhibition. Life Science 2006;79:1561-7
4.	Lock H R, Sacks S H, Robson M G. Rapamycin at sub-immunosuppressive levels inhibits mesangial cell proliferation and extracellular matrix production. Am J Physiol Renal Physiol 2007;292:F76-F81.
5.	Giannico G, Cortes P, Baccora MH, et al. Glibenclamide prevents increased extracellular matrix formation induced by a high glucose concentration in mesangial cells. Am J Physiol physiol Renal 2007;292:F57-F65.