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Saudi Journal of Kidney Diseases and Transplantation
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LETTER TO EDITOR Table of Contents   
Year : 2007  |  Volume : 18  |  Issue : 2  |  Page : 262
Up-Date on Renal Fibrosis: A Time for Action

London NW1 8JS, United Kingdom

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How to cite this article:
Wardle E N. Up-Date on Renal Fibrosis: A Time for Action. Saudi J Kidney Dis Transpl 2007;18:262

How to cite this URL:
Wardle E N. Up-Date on Renal Fibrosis: A Time for Action. Saudi J Kidney Dis Transpl [serial online] 2007 [cited 2023 Jan 29];18:262. Available from: https://www.sjkdt.org/text.asp?2007/18/2/262/32322
To the Editor:

Readers of my original article [1] may have concluded that on the subject of Fibrosis there is a vast amount of theoretical information, [2] but for the working nephrologists there is only the knowledge that treating patients with a combination of ACE inhibitors and ARBs could lessen fibrosis, or alternatively there is the Et-1 antagonist bosentan, which is not entirely free of side-effects.

However there is encouraging news. It is reported that mycophenolate inhibits mesan­gial cell proliferation and reduces the synthe­sis of extracellular matrix. [3] Then low dose rapamycin has been found to act similarly, albeit by a different mechanism. [4] Finally when type II diabetics are taking gliben­clamide this agent stops extracellular matrix formation by mesangial cells exposed to a high glucose. [5]

   References Top

1.Wardle E N. Renal Fibrosis, Origin and possible Interventions:A Time for Action. Saudi J Kidney Dis Transpl 2006;17{2}:137-48.  Back to cited text no. 1    
2.Teng Y, Zeisberg M, Kalluri R. Transcriptional regulation of epithelial­mesenchymal transition. J Clin Invest 2007;117:304-6.  Back to cited text no. 2  [PUBMED]  [FULLTEXT]
3.Ha H, Kim M S, Park J, et al. Mycophenolic acid inhibits mesangial cell activation through p38 MAPkinase inhibition. Life Science 2006;79:1561-7  Back to cited text no. 3    
4.Lock H R, Sacks S H, Robson M G. Rapamycin at sub-immunosuppressive levels inhibits mesangial cell proliferation and extracellular matrix production. Am J Physiol Renal Physiol 2007;292:F76-F81.  Back to cited text no. 4    
5.Giannico G, Cortes P, Baccora MH, et al. Glibenclamide prevents increased extra­cellular matrix formation induced by a high glucose concentration in mesangial cells. Am J Physiol physiol Renal 2007;292:F57-F65.  Back to cited text no. 5    

Correspondence Address:
E Nigel Wardle
London NW1 8JS
United Kingdom
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Source of Support: None, Conflict of Interest: None

PMID: 17496407

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