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Saudi Journal of Kidney Diseases and Transplantation
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EDITORIAL Table of Contents   
Year : 2007  |  Volume : 18  |  Issue : 4  |  Page : 512-522
Nephrotic Proteinuria and the Autonomic Nervous System

Internal Medicine Department, Pisa University, Italy

Correspondence Address:
Marcello Camici
Internal Medicine Department, Pisa University
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Source of Support: None, Conflict of Interest: None

PMID: 17951936

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Nephrotic proteinuria triggers off complex neuro-endocrine mechanisms where forebrain activation results in sympathetic over activity. An attempt is made to discuss and analyze the renal sympathetic efferent nerve hyperactivity, the role played by the angiotensin/nitric oxide system during proteinuria and the nitric oxide/angiotensin imbalance in the hypothalamus. Several questions arise: further experimental and clinical studies are necessary. The answers to these questions may disclose new clinical and therapeutic perspectives for the nephrotic syndrome.

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