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Saudi Journal of Kidney Diseases and Transplantation
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Year : 2010  |  Volume : 21  |  Issue : 2  |  Page : 222-231
Paraneoplastic syndromes and the kidney

Division of Nephrology, Department of Internal Medicine, Walter Cantidio University Hospital, Medicine School, Federal University of Ceara, Brazil

Correspondence Address:
Pedro Henrique de Oliveira Filgueira
Department of Internal Medicine, Division of Nephrology, Walter Cantidio University Hospital, Federal University of Ceara CEP: 60125-001
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Source of Support: None, Conflict of Interest: None

PMID: 20228504

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A paraneoplastic syndrome is defined as a group of symptoms that develop when substances released by some cancer cells disrupt the normal function of the surrounding cells and tissue. Paraneoplastic renal syndromes are diseases that indirectly compromise tubular and glomerular function by electrolyte imbalance, hormone-producing tumors or deposition of antigen-antibody complexes in the glomeruli. In order to describe the most common paraneoplastic syndromes, which may compromise the renal function, an extensive review was performed of papers, including case reports, guidelines, meta-analysis and other scientific publications. Renal function can be affected by many paraneoplactic syndromes: hypercalcemia in malignancies, syndrome of inappropriate sec­retion of antidiuretic hormone, tumor lysis syndrome, renin-producing tumors and paraneoplastic glomerulopathies. An early diagnosis and effective treatment might improve quality of life and alter prognosis of these patients.

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