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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2011  |  Volume : 22  |  Issue : 5  |  Page : 1019-1021
Renal amyloidosis in a child with neutropenia


1 Department of Pediatric Nephrology, Tehran University of Medical Sciences, Ali Asghar Children Hospital, Tehran, Iran
2 Tehran University of Medical Sciences, Ali Asghar Children Hospital, Tehran, Iran
3 Department of Pathology, Tehran University of Medical Sciences, Ali Asghar Children Hospital, Tehran, Iran

Correspondence Address:
Ashkan Heshmatzade Behzadi
Tehran University of Medical Science, Ali Asghar Children Hospital, Tehran
Iran
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Source of Support: None, Conflict of Interest: None


PMID: 21912038

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Amyloidosis represents a heterogeneous group of disorders of protein metabolism and is characterized by deposition of fibrillar proteins in the intra- and extracellular spaces. Here, a case of generalized amyloidosis associated with neutropenia is presented. She had a medical history of multiple bacterial infections. At the age of 14 years, she developed nephrotic syndrome. An increase of antigenic stimulation during the intermittent bouts of acute infections would have been the main factor responsible for the development of secondary amyloidosis in this case. To the best of our knowledge, coexistence between neutropenic disorders and renal amyloidosis in children has not been reported till date. The purpose of this report is to present a case of secondary amyloidosis associated with neutropenia in pediatric age group, probably for the first time.


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