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| CASE REPORT |
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| Year : 2016 |
Volume
: 27 | Issue : 2 | Page
: 407-410 |
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Quadriparesis due to Gitelman's syndrome diagnosed with thiazide diuretic test response
Sumanto Mukhopadhyay, Suvendu Jana, Apratim Chatterjee, Manoj Roy, Anup Sarkar, Jotideb Mukhopadhyay
Department of Internal Medicine, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India
Correspondence Address:
Sumanto Mukhopadhyay
Department of Internal Medicine, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1319-2442.178584
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Gitelman's syndrome is characterized by hypocalciuria, severe hypomagnesemia, and prominent muscular involvements such as fatigue, weakness, cramps, and tetany. It is due to mutations in the thiazide sensitive NaCl co-transporter in the distal convoluted tubule. The administration of thiazide diuretics may induce a subnormal increase of urinary Cl− excretion in patients with Gitelman's syndrome, consistent with the hypothesis that less than normal Cl− is reabsorbed by the thiazide-inhibitable transporter in Gitelman's syndrome. Thus, we report a case of Gitelman's syndrome presenting with quadriparesis diagnosed by using thiazide clearance test. |
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