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Saudi Journal of Kidney Diseases and Transplantation
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ORIGINAL ARTICLE Table of Contents   
Year : 2018  |  Volume : 29  |  Issue : 3  |  Page : 545-553
Combined use of Vitamins E and C improve nephrotoxicity induced by colistin in rats


1 Research Unit of Pharmacology and Toxicology of Xenobiotics (UR12 ES13), Faculty of Medicine, University of Sfax, 3029, Sfax, Tunisia
2 Anatomopathology Laboratory, CHU Habib Bourguiba, University Hospital, Sfax, Tunisia
3 Laboratory of Histology and Embryology, Faculty of Medicine, University of Sfax, Sfax, Tunisia

Correspondence Address:
Dr. Zohra Ghlissi
Laboratory of Pharmacology, Faculty of Medicine, University of Sfax, Sfax
Tunisia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-2442.235168

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This study was performed to investigate the protective effect of combined use of Vitamins E and C on colistin-induced tubular damage in rat. Animals were treated with sterile saline, colistin methanesulfonate (CMS), CMS + Vitamin E + Vitamin C, and Vitamin E + vitamin C, respectively, for seven days. Thereafter, animals were sacrificed and the urine N-acetyl-b-D-glucosaminidase (NAG) and gamma-glutamyl transferase (GGT) levels, plasma level of creatinine (Cr), vitamin E and vitamin C, and renal tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), as well as renal histology were performed. CMS induced acute tubular necrosis, increased the NAG, GGT, and MDA levels, and reduced the Vitamin E, Vitamin C, SOD, CAT, and GPx activities. Co-treatment with vitamins E and C restored all biochemical parameters cited above and improved the histopathological damage. Tubular damage induced by colistin is at least partly due to oxidative stress. Nephroprotective effect of Vitamins E and C is partially mediated through its antioxidant properties, and the higher protection by the combination of these vitamins is related to its synergistic effects.


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