|
CASE REPORT |
|
|
|
Year : 2018 |
Volume
: 29 | Issue : 6 | Page
: 1511-1514 |
|
Short-course metronidazole-induced reversible acute neurotoxicity in a renal transplant recipient
Pavitra Manu Dogra, Anil Kumar Bhatt, Sanjay Kumar Agarwal, Dipankar Bhowmik
Department of Nephrology, All India Institute of Medical Sciences, New Delhi, India
Correspondence Address:
Dr. Pavitra Manu Dogra Department of Nephrology, All India Institute of Medical Sciences, New Delhi India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1319-2442.248315
|
|
Neurotoxic manifestations due to chronic metronidazole intake are well known, but neurotoxicity due to short-term use of metronidazole is very rare. We present a case of acute neurotoxicity due to short course of injectable metronidazole given in usual doses to a renal allograft recipient for persistent diarrhea. It responded to withdrawal of the offending drug. Tacrolimus trough concentration did not increase during neurotoxicity, thereby ruling out any metronidazole-tacrolimus interaction. Magnetic resonance imaging of the brain showed widespread osmotic demyelination and its recovery after drug withdrawal. This is the first reported case of a renal transplant recipient developing acute neurotoxicity due to short-term use of metronidazole, without any increase in tacrolimus trough concentrations. |
|
|
|
[FULL TEXT] [PDF]* |
|
 |
|
|