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Saudi Journal of Kidney Diseases and Transplantation
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Year : 2020  |  Volume : 31  |  Issue : 3  |  Page : 694-695
Coronavirus-antibody immune complex: A nanostructure appraisal possible cause of nephropathology

1 Private Academic Practice, Bangkok, Thailand
2 Department of Community Medicine, Dr. D. Y. Patil University, Pune, Maharashtra, India; Department of Tropical Medicine, Hainan Medical University, Haikou, China

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Date of Submission19-Feb-2020
Date of Acceptance23-Feb-2020
Date of Web Publication10-Jul-2020

How to cite this article:
Sriwijitalai W, Wiwanitkit V. Coronavirus-antibody immune complex: A nanostructure appraisal possible cause of nephropathology. Saudi J Kidney Dis Transpl 2020;31:694-5

How to cite this URL:
Sriwijitalai W, Wiwanitkit V. Coronavirus-antibody immune complex: A nanostructure appraisal possible cause of nephropathology. Saudi J Kidney Dis Transpl [serial online] 2020 [cited 2022 Dec 2];31:694-5. Available from: https://www.sjkdt.org/text.asp?2020/31/3/694/289457

To the Editor,

Coronavirus infection becomes an important problem in public health. Within the past few years, many emerging coronavirus infections occur including to COVID-19.[1] The coronavirus-induced nephropathy is an interesting issue in clinical nephrology. The nephropathological finding is various.[2] In animal, the glomerulopathy by immune complex is an important clinical problem.[3] In fact, immune complex plays important role in many kinds of renal pathology and the underlying pathogenesis might be explained by nanostructure analysis.[4] Here, the authors focus interest on the coronavirus-antibody immune complex. The molecular nanostructure analysis by standard nanomedicine technique as used in the previous reported[5] was done. For prediction of the nanostructure of coronavirus-antibody immune complex, referencing sizes for coronavirus (120–160 nm),[1] immunoglobulin[6] and renal glomerulus (15–30 nm) diameters[5] are referred to. Based on nanostructure viewing of predicted immune complex, the size of coronavirus-antibody immune complex is 135–190 nm. This size is significant larger than glomerular pore size (4–4.5 nm)[4] but smaller than renal tubule (12–50 microns).[7] Therefore, there is a chance that the immune complex of coronavirus-antibody can cause glomerular pathology. This can also explain the observation of no virus in excreted urine during infection.[8]

Conflict of interest: None declared.

Dr. Won Sriwijitalai[1],

   References Top

Weiss SR, Leibowitz JL. Coronavirus pathogenesis. Adv Virus Res 2011;81:85-164.  Back to cited text no. 1
Cha RH, Yang SH, Moon KC, Joh JS, Lee JY, Shin HS, et al. A case report of a Middle East respiratory syndrome survivor with kidney biopsy results. J Korean Med Sci 2016;31:635- 40.  Back to cited text no. 2
Fujii Y, Tochitani T, Kouchi M, Matsumoto I, Yamada T, Funabashi H. Glomerulonephritis in a ferret with feline coronavirus infection. J Vet Diagn Invest 2015;27:637-40.  Back to cited text no. 3
Wiwanitkit V. Glomerular pore size corresponding to albumin molecular size, an explanation for underlying structural pathology leading to albuminuria at nano level. Ren Fail 2006;28:101.  Back to cited text no. 4
Wiwanitkit V. Effect of immune complex on the biomechanics of blood flow in common glomerulonephritis diseases. Ren Fail 2006;28: 541-2.  Back to cited text no. 5
Faber S, Sarkar S, Gill P, Nazari B, Faridania F. High resolution imaging of IgG and IgM molecules by scanning tunneling microscopy in air condition Scientia Iranica 2011;18:1643- 6.  Back to cited text no. 6
Crabbs TA, McDorman KS. Brief synopsis: Review of renal tubule and interstitial anatomy and physiology and renal INHAND, SEND, and DIKI nomenclature. Toxicol Pathol 2018;46:920-4.  Back to cited text no. 7
Farag EA, Haagmans BL, Al-Romaihi H, Mohran K, Haroun M, El-Sayed AM, et al. Failure to detect MERS-CoV RNA in urine of naturally infected dromedary camels. Zoonoses Public Health 2019;66:437-8.  Back to cited text no. 8

Correspondence Address:
Won Sriwijitalai
Private Academic Practice, Bangkok
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1319-2442.289457

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