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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2021  |  Volume : 32  |  Issue : 1  |  Page : 240-244
Splenic Infarcts and Pulmonary Renal Syndrome in a Young Patient with Double-Positive Anti-GBM and ANCA-Associated Vasculitis


1 Department of Medicine, King Abdulaziz Medical City, Ministry of the National Guard- Health Affairs; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia
2 King Abdullah International Medical Research Center; Department of Pathology, KAMC, Ministry of the National Guard- Health Affairs, Riyadh, Saudi Arabia
3 Department of Medicine, King Abdulaziz Medical City, Ministry of the National Guard- Health Affairs, Riyadh, Saudi Arabia

Correspondence Address:
Elwaleed A Elhassan
Nephrology and Renal Transplantation Division, Department of Medicine, KAMC-RD, P. O. Box: 22490, Mail Code 1443, Riyadh 11426
Saudi Arabia
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DOI: 10.4103/1319-2442.318532

PMID: 34145139

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Double-positive disease, defined by double-seropositivity for serum anti-glomerular basement membrane (GBM) antibodies and anti-neutrophil cytoplasmic antibodies (ANCA) is a rare cause of pulmonary-renal syndrome. Here, we present an exceptional course of a 20-year-old male with seropositivity for anti-myeloperoxidase anti-neutrophil cytoplasmic antibodies and anti-GBM antibody, who presented first with renal impairment due to focal necrotizing crescentic glomerulonephritis. After receiving treatment, he presented two years later with a relapse manifesting with diffuse alveolar hemorrhage and multiple splenic infarcts. We discuss the clinical presentation patterns and treatment strategies of this entity.


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