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Saudi Journal of Kidney Diseases and Transplantation
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Year : 2021  |  Volume : 32  |  Issue : 6  |  Page : 1764-1774
Acute Kidney Injury and Mortality among Patients with Coronavirus Disease-2019 in Pakistan

1 Department of Nephrology and Renal Transplantation, Institute of Kidney Diseases Hayatabad, Peshawar, Pakistan
2 Department of Obstetrics and Gynecology, Hayatabad Medical Complex, Peshawar, Pakistan
3 department of Pharmacy, University of Peshawar, Peshawar, Pakistan
4 Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan, Pakistan
5 Department of Pediatrics, Hayatabad Medical Complex, Peshawar, Pakistan
6 Department of Radiology, Institute of Kidney Diseases Hayatabad, Peshawar, Pakistan
7 Institute of Pharmaceutical Sciences, University of Veterinary and Animal Science, Outfall Campus, Civil Lines, Lahore, Pakistan; School of Pharmacy, Monash University, Jalan Lagoon Selatan, Bandar Sunway, Selangor, Malaysia, Pakistan

Correspondence Address:
Raheel Ahmed
Department of Nephrology and Renal Transplantation, Institute of Kidney Diseases, Hayatabad, Peshawar, Pakistan.
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1319-2442.352439

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The kidney is the most vulnerable organ in coronavirus disease-2019 (COVID-19) patients besides the lungs, with evidence of acute kidney injury (AKI). We aimed to find the prevalence of AKI among COVID-19 patients and further evaluate the association of between COVID-19 and AKI along with an understanding of mortality. A prospective observational study was conducted among COVID-19 patients admitted to a tertiary care hospital, Hayatabad Medical Complex, between March 2020 and June 2020. Chi-square test was applied for comparative analysis, whereas for predictors of mortality, odds ratios (OR) were calculated using logistic regression. A total of 606 patients with COVID-19 were admitted to the dedicated ward, of which 250 (41.3%) had AKI and 190 (31.4%) died, whereas, patients having AKI presented 62.1% of mortality. Our study revealed a statistically significant association between AKI and mortality (OR = 3.5; P <0.0001). Moreover, we observed a greater risk of deaths among patients with AKI stage I-III i.e., AKI stage I (OR = 2.4; P <0.0001), stage II (OR = 5.5; P = 0.0001), and stage III (OR = 6.6; P<0.0001). Our study reported AKI and associated mortality in a considerable number of patients with COVID-19. AKI patients have significantly higher chances of death versus non-AKI patients. Further, the risk of mortality increases with further deterioration in kidney function, i.e., patients with AKI stage III showed a higher mortality rate compared with stage II and stage I.

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