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Saudi Journal of Kidney Diseases and Transplantation
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CASE REPORT Table of Contents   
Year : 2021  |  Volume : 32  |  Issue : 6  |  Page : 1826-1829
Anaphylaxis: An Uncommon Cause of Rhabdomyolysis-Related Acute Kidney Injury

1 Department of Medicine, Military Hospital Wellington, Coonoor, Nilgiris, Tamil Nadu, India
2 Department of Nephrology, Medical Division, Command Hospital Air Force, Bengaluru, Karnataka, India

Correspondence Address:
Vijoy Kumar Jha
Department of Nephrology, Medical Divison, Command Hospital Air Force, Bengaluru - 560 007, Karnataka, India.
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1319-2442.352449

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Anaphylaxis is an acute, severe, and potentially lethal form of an allergic reaction. It can lead to a sepsis-like syndrome and multisystem involvement with complications. It can cause distributive shock with preferential blood supply to vital organs, at the expense of blood supply to skeletal muscle. Skeletal muscle ischemia leads to the fast depletion of myocyte energy source and a cascade of inflammatory reactions leading to myocyte injury and death. Myocyte lysis or rhabdomyolysis releases the cellular contents into circulation. Rhabdomyolysis is not an oft-discussed complication of anaphylaxis. We describe a 21-year-old male with no known comorbidity who presented with anaphylactic shock after consuming one tablet paracetamol + ibuprofen and was found to have rhabdomyolysis-related acute kidney injury.

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