Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2007  |  Volume : 18  |  Issue : 4  |  Page : 551--555

Correlation Between Creatinine Clearance and Transtubular Potassium Concentration Gradient in Old People and Chronic Renal Disease Patients


Carlos Musso1, Vassilis Liakopoulos2, Ioanis Stefanidis2, Raul De Miguel3, Nora Imperiali1, Luis Algranati1 
1 Nephrology Deparment, Hospital Italiano de Buenos Aires, Argentina
2 Nephrology Department, Larissa, Greece
3 Laboratory Deparment, Hospital Italiano de Buenos Aires, Argentina

Correspondence Address:
Carlos Musso
Nephrology Department, Hospital Italiano de Buenos Aires, Buenos Aires
Argentina

Senescence and chronic kidney disease (CKD) reduce progressively glomerular filtration rate (GFR), which usually results in an increase in potassium renal secretion. To evaluate whether the transtubular potassium concentration gradient (TTKG) is more accurate parameter for evaluating the renal secretion of this cation than using fractional excretion of potassium as its urinary secretion marker, we studied 55 subjects, 43 of them were healthy elderly volunteers and 12 were CKD patients. Exclusion criteria were: abnormal plasma potassium level or presence of any disease or drug that could induce alteration of balance of this electrolyte levels. All the subjects were on a diet with a potassium content around 50 mmol/day. The curves, which demonstrate the relationship between creatinine clearance and TTKG and the grade of correlation between these two parameters were analyzed in both groups. We found that the transtubular potassium concentration gradient had a significant negative correlation with the creatinine clearance level in the healthy elderly group, while there was no correlation in the CKD group.


How to cite this article:
Musso C, Liakopoulos V, Stefanidis I, De Miguel R, Imperiali N, Algranati L. Correlation Between Creatinine Clearance and Transtubular Potassium Concentration Gradient in Old People and Chronic Renal Disease Patients.Saudi J Kidney Dis Transpl 2007;18:551-555


How to cite this URL:
Musso C, Liakopoulos V, Stefanidis I, De Miguel R, Imperiali N, Algranati L. Correlation Between Creatinine Clearance and Transtubular Potassium Concentration Gradient in Old People and Chronic Renal Disease Patients. Saudi J Kidney Dis Transpl [serial online] 2007 [cited 2023 Jan 28 ];18:551-555
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2007;volume=18;issue=4;spage=551;epage=555;aulast=Musso;type=0