Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2009  |  Volume : 20  |  Issue : 6  |  Page : 1000--1004

Evaluation of serum tumor necrosis factor α and its correlation with histology in chronic kidney disease, stable renal transplant and rejection cases


Gyanendra Kumar Sonkar1, Usha1, RG Singh2 
1 Department of Pathology, Division of Immunopathology, UGC Advanced Immunodiagnostic Training and Research Center, Varanasi, India
2 Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

Correspondence Address:
Usha
UGC Advanced Immunodiagnostic Training and Research Center, Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005
India

Tumor necrosis factor alpha (TNF α) is a cytokine secreted by macrophages, helper T cells, Natural Killer cells, B lymphocytes and non lymphoid cells e.g. endothelial cells, fibroblast and tumor cell lines. Aim of the study was to find the utility of TNF α in diagnosing renal transplant rejection among the renal transplant cases (n=29), and comparison with the levels in patients on maintenance hemodialysis (n=21) and healthy controls (n=20). TNF α in healthy controls varied from 2 to 15 pg/mL. In chronic renal failure and renal transplant rejection cases TNF α was above 45 pg/mL. In stable renal transplant patients it was higher than normal (16 to 30 pg/mL). In both acute and chronic transplant rejection TNF α increase correlated well with histology. Thus our study suggests that TNF a level more than 45 pg/mL can be taken as an immunological marker of renal transplant rejection.


How to cite this article:
Sonkar GK, Usha, Singh R G. Evaluation of serum tumor necrosis factor α and its correlation with histology in chronic kidney disease, stable renal transplant and rejection cases.Saudi J Kidney Dis Transpl 2009;20:1000-1004


How to cite this URL:
Sonkar GK, Usha, Singh R G. Evaluation of serum tumor necrosis factor α and its correlation with histology in chronic kidney disease, stable renal transplant and rejection cases. Saudi J Kidney Dis Transpl [serial online] 2009 [cited 2022 Sep 27 ];20:1000-1004
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2009;volume=20;issue=6;spage=1000;epage=1004;aulast=Sonkar;type=0