Saudi Journal of Kidney Diseases and Transplantation

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 25  |  Issue : 3  |  Page : 577--581

Single nucleotide polymorphisms at erythropoietin, superoxide dismutase 1, splicing factor, arginine/serin-rich 15 and plasmacytoma variant translocation genes association with diabetic nephropathy


Maisaa Alwohhaib1, Salah Alwaheeb2, Nour Alyatama3, Ali A Dashti1, Amal Abdelghani4, Naser Hussain4 
1 Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Health Science Center, Kuwait
2 Department of Pathology, Faculty of Medicine, Health Science Center, Kuwait
3 Department of Internal Medicine, Farwaniyah Hospital, Kuwait
4 Nephrology Department, Mubarak Al-Kabeer Hospital, Kuwait

Correspondence Address:
Dr. Maisaa Alwohhaib
Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Health Science Center
Kuwait

A number of genes have been identified in diabetic nephropathy. Association between diabetes-associated nephropathy and polymorphisms in the erythropoietin (EPO) gene, variants in the superoxide dismutase 1 (SOD1) gene and plasmacytoma variant translocation 1 (PVT1) gene have been identified. The EPO, SOD1:SFRS15 and PVT1 genes were genotyped using the single nucleotide polymorphism (SNP) technique in 38 diabetic nephropathy patients (Group 1) compared with 64 diabetic type 2 subjects without nephropathy (Group 2) at the Mubarak Alkabeer Hospital, Kuwait. The frequency of the risk allele T of the EPO (rs1617640) gene was high in both groups (0.96 in Group 1 and 0.92 in Group 2). Similarly, SNPs of the PVT1 (rs2720709) gene showed a higher frequency of the risk allele G in both groups (0.70 in the Group 1 and 0.68 in Group 2). Although the frequency of the risk allele A was higher than the frequency of the non-risk allele C of the SOD1:SFRS15 gene in both groups, the lowest probability value was observed in those gene SNPs (P = 0.05). We observed that the A allele of the SOD1:SFRS15 gene (rs17880135) was more frequently present in Group 1 (0.75) compared with Group 2 (0.62). Susceptibility to diabetes-associated nephropathy is partially mediated by genetic predisposition, and screening tests may open the gate for new therapeutic approaches.


How to cite this article:
Alwohhaib M, Alwaheeb S, Alyatama N, Dashti AA, Abdelghani A, Hussain N. Single nucleotide polymorphisms at erythropoietin, superoxide dismutase 1, splicing factor, arginine/serin-rich 15 and plasmacytoma variant translocation genes association with diabetic nephropathy.Saudi J Kidney Dis Transpl 2014;25:577-581


How to cite this URL:
Alwohhaib M, Alwaheeb S, Alyatama N, Dashti AA, Abdelghani A, Hussain N. Single nucleotide polymorphisms at erythropoietin, superoxide dismutase 1, splicing factor, arginine/serin-rich 15 and plasmacytoma variant translocation genes association with diabetic nephropathy. Saudi J Kidney Dis Transpl [serial online] 2014 [cited 2022 Jun 26 ];25:577-581
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2014;volume=25;issue=3;spage=577;epage=581;aulast=Alwohhaib;type=0