Saudi Journal of Kidney Diseases and Transplantation

RENAL DATA FROM ASIA–AFRICA
Year
: 2018  |  Volume : 29  |  Issue : 3  |  Page : 649--657

Albuminuria status and patterns of dyslipidemia among type 2 diabetes black patients managed at a tertiary health-care hospital: A Post hoc analysis


Francois M Kajingulu1, Francois B Lepira1, Fiston I Mbutiwi2, Jean-Robert Makulo1, Ernest K Sumaili1, Justine B Bukabau1, Vieux M Mokoli1, Augustin L Longo1, Nazaire M Nseka1 
1 Department of Internal Medicine, Division of Nephrology, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo
2 Department of Internal Medicine, Division of Nephrology, University Hospital of Kinshasa, University of Kinshasa, Kinshasa; Faculty of Medicine, University of Kikwit, Kikwit, Democratic Republic of Congo

Correspondence Address:
Dr. Francois M Kajingulu
Department of Internal Medicine, Division of Nephrology, University of Kinshasa, Kinshasa
Democratic Republic of Congo

Cardiovascular disease (CVD) risk in type 2 diabetes mellitus (T2DM) increases with the development of albuminuria and is related in part to dyslipidemia. The present analysis assessed lipid profile and patterns of dyslipidemia in T2DM patients according to albuminuria status. This was a post hoc analysis of data from 181 T2DM patients seen at a tertiary health-care hospital and enrolled in a cross-sectional study of albuminuria status. Abnormal albuminuria was defined as microalbuminuria [albumin to creatinine ratio (ACR) 30-299.9 mg/g] or macro-albuminuria (ACR ≥300 mg/g). Atherogenic dyslipidemia was defined as triglycerides (TGs) ≥150 mg/dL and/or high-density lipoprotein-cholesterol (HDL-c) <40 mg/dL in men and <50 mg/dL in women using international consensus criteria. High levels of total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), HDL-c, non-HDL-c, TG, and low level of HDL-c were defined according to 2012 American Association of Clinical Endocrinologists' guidelines. Comparisons between T2DM patients with and without abnormal albuminuria were done using Chi-square test, Student's t-test, or two-sample t-test with equal variance and Mann-Whitney test as appropriate. P< 0.05 defined the level of statistical significance. Of the 181 T2DM patients, 93 (51%) had abnormal albuminuria with 32% and 19% having microalbuminuria and macro-albuminuria, respectively. Average TC, HDL-c, HDL-c, non-HDL-c, and TG levels were 171 ± 41, 111 ± 36, 38 ± 16, 133 ± 38, and 98 (45-234) mg/dL, respectively. These values were significantly lower for TC (P = 0.047), LDL-c (P = 0.030), and non-HDL-c (P = 0.05) in comparison with patients with normal albuminuria. Low HDL-c (64.5%) and high TG (9.7%) were, respectively, the most and less frequent patterns of isolated dyslipidemia in patients with abnormal albuminuria. Atherogenic dyslipidemia with mainly low HDL-c levels is common in T2DM patients with abnormal albuminuria and could contribute to CVD and renal disease progression.


How to cite this article:
Kajingulu FM, Lepira FB, Mbutiwi FI, Makulo JR, Sumaili EK, Bukabau JB, Mokoli VM, Longo AL, Nseka NM. Albuminuria status and patterns of dyslipidemia among type 2 diabetes black patients managed at a tertiary health-care hospital: A Post hoc analysis.Saudi J Kidney Dis Transpl 2018;29:649-657


How to cite this URL:
Kajingulu FM, Lepira FB, Mbutiwi FI, Makulo JR, Sumaili EK, Bukabau JB, Mokoli VM, Longo AL, Nseka NM. Albuminuria status and patterns of dyslipidemia among type 2 diabetes black patients managed at a tertiary health-care hospital: A Post hoc analysis. Saudi J Kidney Dis Transpl [serial online] 2018 [cited 2022 May 23 ];29:649-657
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2018;volume=29;issue=3;spage=649;epage=657;aulast=Kajingulu;type=0