Saudi Journal of Kidney Diseases and Transplantation

RENAL DATA FROM ASIA–AFRICA
Year
: 2018  |  Volume : 29  |  Issue : 3  |  Page : 680--688

Primary IgA nephropathy in the Kashmiri population


Abdul Majeed Chowdry, Mohd. Saleem Najar, Mohamad Muzzafer Mir, Hilal Azad, Reshi Abdul Rashid, Bhat Mohd. Ashraf, Bhanday Khursheed Ahmed, Wani Muzafar Maqsood, Wani Imtiaz Ahmed 
 Department of Nephrology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India

Correspondence Address:
Dr. Abdul Majeed Chowdry
Department of Nephrology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir
India

IgA nephropathy (IgAN) remains one of the most common glomerular lesions, which has a striking geographic distribution and is the most common form of primary glomerular disease in Asia. However, the exact prevalence or clinicopathological spectrum of IgAN in India is not well documented. This retrospective study analyzed the presentation in 126 patients of primary IgAN out of 298 native kidney biopsies (42.28%) performed over a period of three years (2013–2015). The patients were followed up for three months. This is the second highest prevalence recorded in the world after Japan. Among the clinical features of our cohort, the mean age was 31 years, with a male-to-female ratio of 2:1, with the highest incidence observed in the third decade of life in both sexes. The majority of our patients (47%) presented with renal failure with a mean serum creatinine value of 3.1 mg/dL and with burnt out morphology on histo-pathology; 72.2% of patients were hypertensive at presentation. On histopathology, Haas class V (35.5%) had the highest frequency followed by class IV (25.8%). The Oxford MEST score was not applicable in 36 patients because of advanced sclerosis (>50%). In the remaining ninety patients, majority had tubular atrophy and interstitial fibrosis of varying degrees. At three months of follow-up, the patients who had presented with renal failure (47.6%), settled in chronic kidney disease stage III (25.4%) followed by stage IV (18.6%) and stage V (11.8%). Our study in Kashmir suggests that IgAN is more common in the younger age group, with a significant number of patients presenting with advanced renal failure and, on morphology, showing a burnt out disease, with many developing end-stage renal disease. Studies evaluating the underlying factors can have immense importance in dealing with the disease.


How to cite this article:
Chowdry AM, Najar MS, Mir MM, Azad H, Rashid RA, Ashraf BM, Ahmed BK, Maqsood WM, Ahmed WI. Primary IgA nephropathy in the Kashmiri population.Saudi J Kidney Dis Transpl 2018;29:680-688


How to cite this URL:
Chowdry AM, Najar MS, Mir MM, Azad H, Rashid RA, Ashraf BM, Ahmed BK, Maqsood WM, Ahmed WI. Primary IgA nephropathy in the Kashmiri population. Saudi J Kidney Dis Transpl [serial online] 2018 [cited 2022 May 23 ];29:680-688
Available from: https://www.sjkdt.org/article.asp?issn=1319-2442;year=2018;volume=29;issue=3;spage=680;epage=688;aulast=Chowdry;type=0